Chronic Risk Essay Example | Topics and Well Written Essays - 250 words

Chronic Risk - Essay Example Patterns of gene expressions were then determined using DNA microarrays (Moore, 2003). In all cases there were common responses and different responses. Chromium, nickel and cadmium were found to induce oxidative stress that had unique and similar pathways and genes that responded to the stress. All of them were found to be genotoxic. However, DNA damage was found to occur in chromium responses only. It was found that Nickel resulted to hypoxic response induction and chromatin structure gene induction. It did this by replacing the iron in key proteins (Allan, 2007). On the other hand, Cadmium resulted to genes that were perturbed distinctly. These genes related to stress from the endoplasmic reticulum. It also invoked unfolded protein response and led to apoptosis. It is evident that the only biological process that was perturbed to all these metals is the oxidative stress (Gurjar, 2010). This is an effect that is well of these metals. However, the difference that is very notable is the gene modulation involved in anti-oxidant protein glutathione production. This is as a response to nickel. It is also as a result of endoplasmic reticulum (ER) stress that is ROS-induced in response to cadmium (Moore, 2003). Moore, C. E. (2003).  The spectra of chromium, manganese, iron, cobalt, nickel, copper, zinc, gallium, germanium, arsenic, selenium, bromine, krypton, rubidium, strontium, yttrium, zirconium, and